解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The mode of action of steroid hormones has been extended in recent years. In addition to their classical nuclear action (acting as transcription factors), they can also regulate cell-signaling phosphorylation cascades and exert actions that are initiated at the membrane and which, in most cases, are rapid. Even though...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2007.12.009
更新日期:2008-10-01 00:00:00
abstract::Human progesterone receptor (PR) contains a polyproline motif in the amino-terminal domain that interacts with the SH3 domain of Src and mediates rapid activation of c-Src and downstream MAPK (Erk-1/-2) independent of the transcriptional activity of PR. Forcedly target PR to different locations in the cell by use of m...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2008.01.010
更新日期:2008-10-01 00:00:00
abstract::Antiandrogens are widely used agents for the treatment of androgen dependent diseases as inhibitors of androgen receptors (AR) action. Although the precise mechanism of antiandrogen action is not yet elucidated, recent studies indicate the involvement of the structure of the ligand in relation with the nuclear co-repr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.03.006
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Urinary steroid profiling by GC or GC-MS are established clinical tools to complement other biochemical tests in the diagnosis and investigation of a wide range of adrenocortical disorders, but normative data on adults using the more specific GC-MS are lacking. Our objective was to set up the reference inter...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.03.004
更新日期:2008-09-01 00:00:00
abstract::The mechanistic aspects of the alkali-catalyzed rearrangement of 16alpha-hydroxy-17-keto steroid 1 to 17beta-hydroxy-16-keto steroid 2 are elucidated by use of (18)O- and deuterium-labeling experiments. The (18)O-labeling experiments refute the gem-hydration-quasi-diaxial dehydration mechanism for the rearrangement pr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.03.001
更新日期:2008-09-01 00:00:00
abstract::Due to their high profile biological activity, the steroids are among the most important secondary metabolites. A review of literature on the synthesis of pentacyclic steroids is presented. ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2008.04.005
更新日期:2008-09-01 00:00:00
abstract::The full assignments of the (1)H and (13)C NMR signals of steroids bearing the 16beta,23:23,26-diepoxy side chain are provided. Differentiation of the diasterotopic H-26 pair was achieved with the aid of NOESY experiments. The main substituent and steric effects associated with this moiety and their influence on the c...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.01.027
更新日期:2008-07-01 00:00:00
abstract::The preparation of 3-oxo-4-azasteroid from A-nor-3,5-secosteroid-3-oic acid is described in a solventless condition catalysed by Lewis acid under microwave irradiation. We utilized urea as an environmentally benign source for the generation of ammonia for the aza cyclization reaction. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.01.022
更新日期:2008-07-01 00:00:00
abstract::Oxidative stress is thought to play a crucial role in the pathogenesis of chronic diabetic complications. We investigated the protective effects of 17 beta-estradiol (E2) on alloxan-induced stress oxidant, hepatic dysfunction and histological changes in male rats liver and pancreas. Our results showed that 17 beta-est...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.12.026
更新日期:2008-05-01 00:00:00
abstract::This study aimed to develop a quantitative and in vivo magnetic resonance imaging (MRI) approach to investigate the muscle growth effects of anabolic steroids. A protocol of MRI acquisition on a standard clinical 1.5 T scanner and quantitative image analysis was established and employed to measure the individual muscl...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.12.011
更新日期:2008-04-01 00:00:00
abstract::We investigated the modulatory effect of estriol (E(3)), an estrogen predominantly produced during human pregnancy, on the antigen-induced production of specific antibodies in female BALB/c mice, and its effect was compared with 17beta-estradiol (E(2)). Estriol (E(3)) had a very different effect than E(2) on the antig...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.10.012
更新日期:2008-03-01 00:00:00
abstract::Urinary steroid profile analysis requires enzymatic hydrolysis of glucuronide and sulfate conjugates and this is achieved simultaneously using Helix pomatia juice (HPJ), but steroids with 3beta-hydroxy-5-ene structure undergo transformation and yield of 5alpha-reduced corticosteroid glucuronides is poor. We describe t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.11.001
更新日期:2008-03-01 00:00:00
abstract::Using beta-sitosterol as a starting material, (6E)-hydroximino-24-ethylcholest-4-en-3-one (1), a natural steroidal oxime from Cinachyrella alloclada and C. apion, was synthesized in four steps with a high overall yield. First, beta-sitosterol (5a) is transformed into the corresponding 24-ethylcholest-4-en-3,6-dione (6...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.10.007
更新日期:2008-03-01 00:00:00
abstract::The syntheses and antimitotic activity of several novel 18a-homo-analogs of 2-methoxyestradiol are described. Structural modifications of the parent 2-methoxy-18a-homoestradiol include introduction of unsaturation in the D-ring and methylation of the 17-OH. Of seven analogs synthesized, one has demonstrated superior b...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.11.003
更新日期:2008-02-01 00:00:00
abstract::The potent antiproliferative effect of progestins has been utilized in clinical regimens for treatment of endometrial proliferative disorders. The progestin infiltrated intrauterine device used as therapy for endometrial carcinoma as well as endometrial hyperplasia yields a hundred-fold increase of local progestin con...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.09.010
更新日期:2008-01-01 00:00:00
abstract::In our effort to develop imaging agents for brain glucocorticoid receptors, we have prepared several novel glucocorticoids possessing a 2-methylsulfanyl-acetyl side chain. The synthesis was accomplished via a Mitsunobu reaction with thiobenzoic acid starting from cortisol, prednisolone, dexamethasone and triamcinolone...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.08.013
更新日期:2008-01-01 00:00:00
abstract::The metabolism of tamoxifen is being redefined in the light of several important pharmacological observations. Recent studies have identified 4-hydroxy N-desmethyltamoxifen (endoxifen) as an important metabolite of tamoxifen necessary for antitumor actions. The metabolite is formed through the enzymatic product of CYP...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2007.07.009
更新日期:2007-11-01 00:00:00
abstract::Smith-Lemli-Opitz syndrome (SLOS) is caused by deficiency in the terminal step of cholesterol biosynthesis, which is catalyzed by 7-dehydrocholesterol reductase (DHCR7). The disorder exhibits several phenotypic traits including dysmorphia and mental retardation with a broad range of severity. Pathogenesis of SLOS is c...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.07.002
更新日期:2007-10-01 00:00:00
abstract::A rapid and efficient synthesis of 6E-hydroximinosteroid homodimers is described. The two new compounds were linked at position 3 of the steroid nucleus via a ruthenium catalyzed cross-metathesis reaction. The cytotoxic activity of these compounds was evaluated in vitro on human lung carcinoma A549 (ATCC CCL-185), col...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.03.014
更新日期:2007-10-01 00:00:00
abstract::A highly sensitive and specific quantification method of estrone and estradiol in human serum was described based upon the use of picolinoyl derivatization and liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) in a positive mode. Estrogens were treated with picolinoyl chloride hydrochloride o...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.07.003
更新日期:2007-10-01 00:00:00
abstract::The crystal structures of chenodeoxycholic acid (CDCA), ursodeoxycholic acid (7beta isomer of CDCA) and their other two epimers (3beta,7alpha- and 3beta,7beta-isomers) have been resolved. The four isomers were recrystallized from p-xylene. CDCA crystal is hexagonal P6(5) while the crystals of the other three isomers a...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.03.007
更新日期:2007-06-01 00:00:00
abstract::The chemoselectivity of rigid cyclic alpha,beta-unsaturated carbonyl group on the reducing agents was influenced by the ring size and steric factor. Cholesterol (cholest-5-en-3beta-ol) and dehydroepiandrosterone (DHEA) were oxidized with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to form 1,4,6-cholestatrien-3-one and 1...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2006.12.008
更新日期:2007-04-01 00:00:00
abstract::The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived from endogenous metabolism and of exogenous chemicals, in order to enhance their elimination. This unique function of CAR and PXR sets them apart from the ster...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2006.12.006
更新日期:2007-03-01 00:00:00
abstract::Lung cancer is the most common cause of cancer mortality in male and female patients in the US. The etiology of non-small cell lung cancer (NSCLC) is not fully defined, but new data suggest that estrogens and growth factors promote tumor progression. In this work, we confirm that estrogen receptors (ER), both ERalpha ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2006.11.019
更新日期:2007-02-01 00:00:00
abstract::Inhaled corticosteroids (ICS) are the standard of care in asthma and are widely used in the treatment of patients with COPD. The influence of steroids on inflammatory processes has long been established since glucocorticoids and their receptor belong to the regulatory network involved in inhibition of several inflamma...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2006.10.007
更新日期:2007-01-01 00:00:00
abstract::This article describes the origins and evolution of "antiestrogenic" medicines for the treatment and prevention of breast cancer. Developing drugs that target the estrogen receptor (ER) either directly (tamoxifen) or indirectly (aromatase inhibitors) has improved the prognosis of breast cancer and significantly advanc...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2006.10.009
更新日期:2007-01-01 00:00:00
abstract::A mechanistic study on the nucleophilic substitution of a strictly geometric 21-bromo-3alpha-hydroxyl-3beta-methoxymethyl-5alpha-pregnan-20-one was described. Reaction of the alpha-bromoketone with excess lithium imidazole followed by the addition of extra bases including n-butyllithium, methyllithium, lithium piperid...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2006.07.004
更新日期:2006-11-01 00:00:00
abstract::Three new pregnane steroids, 2beta,3beta,5beta-trihydroxy-pregn-20-en-6-one (1), 3beta-hydroxy-5alpha-pregn-7,20-dien-6-one (2), and 3beta-acetoxy-5alpha-pregn-7,20-dien-6-one (3) were isolated from the twigs and leaves of Turraea pubescens, and were structurally elucidated on the basis of spectroscopic data and chemi...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2006.04.010
更新日期:2006-08-01 00:00:00
abstract::Membrane-initiated cellular responses to steroids include modulation of ion channel activities via signal transduction pathways. However, the molecular mechanisms involved in nongenomic actions remain only partially understood. Our research has focused on the rapid effects of 1alpha,25(OH)(2) Vitamin D(3) [1,25D] on L...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.09.012
更新日期:2006-04-01 00:00:00
abstract::Plant lignans are currently being widely studied for their potential benefits for human health as their consumption has been correlated with lower risks for developing chronic diseases, such as breast cancer and coronary heart disease. However, studies of some classes of lignans, in particular the furofurans, are hamp...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.10.005
更新日期:2006-03-01 00:00:00
abstract::The common disease asthma is characterized by the obstruction, inflammation and increased sensitivity of the airways. Glucocorticoids (GCs) are one of the most potent anti-inflammatory agents available for treating allergic disease. In this study, we report that the GC budesonide (BUD) can rapidly inhibit the histamin...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.09.019
更新日期:2006-02-01 00:00:00
abstract::Parathyroid hormone-related protein (PTHrP) increases the growth and osteolytic potential of prostate cancer cells, making it important to control PTHrP expression in these cells. We show that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its non-hypercalcemic analog, EB1089, decrease PTHrP mRNA and cellular protein leve...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.08.009
更新日期:2006-02-01 00:00:00
abstract::Neutral steroids are difficult to analyse using desorption ionisation methods coupled with mass spectrometry (MS). However, steroids with an unhindered ketone group can readily be derivatised with the Girard P (GP) reagent to give GP hydrazones. Steroid GP hydrazones contain a quaternary nitrogen atom and are readily ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.08.002
更新日期:2006-01-01 00:00:00
abstract::Steroids with 4-ene-3,6-dione functionality have application in natural product chemistry, as synthetic intermediates and as aromatase inhibitors. Here, we report a two-phase oxidation of a range of steroidal 5-en-3beta-ols into corresponding 4-ene-3,6-diones using a modified Jones oxidation. The new reaction affords ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.07.007
更新日期:2006-01-01 00:00:00
abstract::Tibolone is a highly effective postmenopausal hormone treatment that has its biological activity dependent on metabolism to 3alpha- and 3beta-OH tibolone, which bind solely to the estrogen receptor. Despite the high levels of estrogen receptor-binding metabolites in the circulation, the endometrium becomes atrophic, s...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.04.010
更新日期:2005-11-01 00:00:00
abstract::Different phytoestrogens were tested as inhibitors of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus (17beta-HSDcl), a member of the short-chain dehydrogenase/reductase superfamily. Phytoestrogens inhibited the oxidation of 100microM 17beta-hydroxyestra-4-en-3-one and the reduction of 100micr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.02.022
更新日期:2005-08-01 00:00:00
abstract::A new synthesis of both epimeric forms of 26-cholestanoic acids and 26-alcohols containing a 3beta-hydroxy-Delta(5)- or a Delta(4)-3-keto-functionality in ring A is described starting from stigmasterol or (20S)-3beta-acetoxy-pregn-5-en-20-carboxylic acid. The obtained compounds are useful as standards for studies of c...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.02.014
更新日期:2005-07-01 00:00:00
abstract::There are currently two main candidates for the membrane receptor for 1,25(OH)2D3: the 1,25D3-MARRS protein/ERp57; and the classical VDR. The 1,25D3-MARRS protein is essential for hormone-stimulated phosphate and calcium uptake in chick intestinal cells, whereas the VDR is not. The 1,25D3-MARRS protein also shows a hi...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2005.02.005
更新日期:2005-05-01 00:00:00
abstract::Extranuclear estrogen receptors may mediate rapid effects of estradiol that communicate with nuclear receptors and contribute to proliferation of human cancers bearing these signaling proteins. To assess these growth-promoting pathways, we undertook controlled homogenization and fractionation of NIH-H23 non-small cell...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.02.017
更新日期:2005-05-01 00:00:00
abstract::The hypothesis tested in the present work is that estrone non-genomically regulates aortic nitric oxide synthase (NOS) and cyclooxygenase (COX) activities in female rats, and that such regulation depends on ovarian function. We found that physiological concentrations of estrone (E(1)) (0.1-10nM) significantly increase...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.10.012
更新日期:2005-04-01 00:00:00